Effects of Early and Late Parenteral Nutrition on Clinical Outcomes in Very Low Birth Weight Preterm Infants: A Systematic Review and Meta-analysis

Parenteral nutrition (PN) in VLBW premature neonates is one of the most important treatment regimes in the early life. Though it is proved as a lifesaving option, but still there are several opinions on its administration. Some researches support the early administration, whereas other supports late one. In this study we hypothesize that early PN has associated with comparative beneficial improvements in the clinical outcomes. We try to explore the effect of early and late administration of PN on the account of different clinical outcomes, such as sepsis, Broncho-Pulmonory Disease (BPD), Intraventricular Haemorrhage (IVH), Mortality, Patent Ductus Arteriosus (PDA), Necrotizing Entercolitis (NEC) and Retinopathy of Prematurity (ROP).